Advanced sleep phase syndrome 2 is a circadian rhythm condition that causes people to get sleepy very early in the evening and wake up very early in the morning. Many people with Advanced sleep phase syndrome 2 feel refreshed at dawn but struggle with evening social or work plans. Symptoms can range from mild schedule shifts to significant daytime sleepiness if bedtimes are delayed, and early symptoms of Advanced sleep phase syndrome 2 may be mistaken for insomnia. It often starts in adolescence or adulthood, can run in families, and is long-lasting but not life-threatening. Treatment focuses on shifting the body clock with timed evening light exposure, morning light avoidance, consistent sleep schedules, and sometimes melatonin under medical guidance.
Overview
Advanced sleep phase syndrome 2Symptoms
Early symptoms of Advanced sleep phase syndrome 2 include intense evening sleepiness, nodding off very early, and waking up before dawn. Sleep is usually refreshing on an earlier schedule, but late social plans, shift work, or travel can be difficult.
Outlook and prognosis
Most people with advanced sleep phase syndrome 2 do well once their schedule and light exposure are adjusted. Symptoms often improve with evening light therapy, carefully timed melatonin, and consistent routines. Long term, sleep quality and daytime function can remain stable.
Causes and risk factors
Often results from inherited variants in circadian clock genes, typically running in families; new mutations can occur. Older age, morning light exposure, early routines, and caffeine or medication timing may further advance sleep timing in Advanced sleep phase syndrome 2.
Genetic influences
Genetics play a major role in Advanced sleep phase syndrome 2. Variants in clock-related genes can shift the internal body clock earlier, causing earlier sleep and wake times. Family clustering is common, suggesting strong heritability alongside environmental influences.
Diagnosis
Doctors look for a long-standing pattern of early sleep and wake times, confirmed with sleep logs or actigraphy. An overnight study helps exclude other sleep disorders. With family history, genetic diagnosis of Advanced sleep phase syndrome 2 may be considered.
Treatment and drugs
Advanced sleep phase syndrome 2 is managed by shifting the body clock later and supporting steady sleep routines. Care often includes evening bright-light therapy, careful morning light avoidance, timed melatonin in early evening, and consistent schedules. A sleep specialist tailors timing and dosage.
Symptoms
Evening plans may feel like a race against your own sleepiness, while mornings start much earlier than you’d like. Advanced sleep phase syndrome 2 shifts your natural sleep window earlier than most people’s, so you get sleepy early and wake up very early. In daily routines, this might show up as small but noticeable changes. You might notice early features of Advanced sleep phase syndrome 2 such as heavy evening drowsiness, early-morning awakenings, and feeling well-rested if you can follow this earlier schedule.
Many people feel very sleepy in the early evening, often around 18:00–20:00 (6–8 pm). With Advanced sleep phase syndrome 2, the drive for sleep arrives earlier than most people's. Staying up past this window can be hard.
You wake up much earlier than planned, often 03:00–05:00 (3–5 am), and cannot fall back asleep. Sleep often feels complete by that time, rather than cut short. This can be frustrating when your household is still asleep.
When you can follow the earlier schedule, sleep is deep and refreshing. People with Advanced sleep phase syndrome 2 often get a normal total amount of sleep. The main issue is timing, not the ability to sleep.
Late events, evening shifts, or long dinners can feel exhausting. Keeping attention and mood steady gets harder as the evening progresses. Unintended dozing may happen in quiet settings.
How people usually first notice Advanced sleep phase syndrome 2?
People often first notice advanced sleep phase syndrome when evenings feel like a wall comes down early: you’re irresistibly sleepy in the early evening and then wide awake hours before dawn, even on weekends. Family or coworkers may point it out first, because you’re nodding off during late activities and waking long before anyone else, and attempts to “push bedtime later” fail, leading to daytime sleepiness or missed social plans. Doctors usually recognize the pattern by your sleep history and sometimes with sleep logs or actigraphy, and in “advanced sleep phase syndrome 2,” the timing tendency can run in families, so noticing similar early-sleep patterns in close relatives can be a clue to the first signs of advanced sleep phase syndrome 2.
Types of Advanced sleep phase syndrome 2
Advanced sleep phase syndrome 2 is generally considered a genetic sleep-wake timing condition with recognized clinical variability rather than many distinct named subtypes. Researchers link it to changes in genes that help set the body clock, which can shift sleep and wake times hours earlier than typical. Not everyone will experience every type. When people talk about symptoms, they often mean one of these kinds:
Classic early sleep
Bedtime and wake time are consistently much earlier than social norms. People often fall asleep in the early evening and wake naturally in the early morning. Daytime function is usually good if sleep is protected.
Family-linked pattern
Multiple relatives across generations show the same early shift in sleep and wake times. This pattern supports a genetic form of advanced sleep phase syndrome 2. Symptoms often start in adolescence or early adulthood and remain stable.
Mild/partial shift
Sleep and wake times are only 1–2 hours early compared with peers. People may manage well on workdays but feel out of sync on weekends. Early symptoms of advanced sleep phase syndrome 2 can be subtle and easy to miss.
Age-amplified variant
The early schedule becomes more pronounced with age, especially after midlife. Evening alertness drops and early morning wakefulness strengthens. Light exposure patterns and routine can further magnify the shift.
Comorbid mood impact
The early sleep schedule contributes to low mood or irritability when social or work demands force later bedtimes. Sleep curtailment often leads to early-morning awakenings with insufficient total sleep. Symptoms usually improve when schedules align with the advanced phase.
What genetics can tell you about symptoms
In Advanced sleep phase syndrome 2, variants in the PER2 gene shift the body clock earlier, so people feel sleepy in the early evening and wake very early, often before dawn. These changes also tighten sleep timing, making naps and staying up late difficult.
Causes and risk factors
Advanced sleep phase syndrome 2 most often stems from a single change in a body clock gene that shifts sleep earlier. It often runs in families, and sometimes the change appears for the first time in one person. Older age, early morning light, low evening light, and very early routines can push the clock further forward. Genes set the stage, but environment and lifestyle often decide how the story unfolds. Knowing your family history and daily light habits can help you notice early symptoms of Advanced sleep phase syndrome 2 and seek advice.
Environmental and biological risk factors
Advanced sleep phase syndrome 2 is uncommon, and most cases start very early in development. Doctors often group risks into internal (biological) and external (environmental). Here, we’re focusing only on environmental and biological influences tied to the chance of it occurring, which is different from day-to-day triggers. If you’re looking for risk factors for Advanced sleep phase syndrome 2, the points below cover the most established ones.
Fathers aged 40 years or older at conception have higher rates of brand-new changes in sperm cells. This slightly increases the chance that a child is born with Advanced sleep phase syndrome 2. The absolute risk remains low.
Age-related changes in egg cells can slightly raise the chance of a one-time change at conception. The effect for this condition appears smaller than for paternal age but may still contribute. Most pregnancies at older ages do not result in Advanced sleep phase syndrome 2.
Occasionally, a chance change happens as the first cells of the embryo divide, without being present in either parent. This can lead to Advanced sleep phase syndrome 2 in a child with no prior family history. There is no known way to predict these rare events.
High-dose ionizing radiation to the pelvis or reproductive organs before conception can damage sperm or eggs. In theory, this may raise the chance of a new change that results in Advanced sleep phase syndrome 2. Such exposures are uncommon, and any individual risk is still low.
Genetic risk factors
Advanced sleep phase syndrome 2 is most often linked to changes in a body-clock gene called CSNK1D, which alter the timing signals that set sleep and wake times. Carrying a genetic change doesn’t guarantee the condition will appear, but it can raise the chance of very early bedtimes and wake-ups in affected families. For some, these early shifts are the first signs; early symptoms of Advanced sleep phase syndrome 2 can include consistently falling asleep and waking much earlier than others in the household. Inheritance is typically autosomal dominant, so the tendency can pass from one generation to the next.
CSNK1D variants: Changes in the casein kinase 1 delta (CSNK1D) gene can speed up the internal clock. This shortens the daily cycle, shifting sleep and wake times earlier.
Autosomal-dominant inheritance: One altered copy of the gene is enough to increase risk. Each child of an affected parent has about a 50% chance of inheriting the change.
Variable expression: The same CSNK1D change can look different from one person to another. Some have very early sleep times, while others have only a modest shift.
Other clock genes: Rare changes in other circadian genes, such as PER2 or CRY2, can also cause advanced sleep timing. When present, these represent related conditions rather than Advanced sleep phase syndrome 2.
Lifestyle risk factors
Lifestyle habits don’t cause Advanced sleep phase syndrome 2, but they can strengthen or soften its tendency toward very early sleep and wake times. Understanding how lifestyle affects Advanced sleep phase syndrome 2 can help you manage daytime function and social schedules. The elements below highlight lifestyle risk factors for Advanced sleep phase syndrome 2 by showing which habits push your body clock even earlier.
Getting bright light soon after waking further advances your internal clock. This can make you sleepy even earlier in the evening and lead to even earlier morning awakenings.
Vigorous exercise in the early morning tends to shift circadian timing earlier. In Advanced sleep phase syndrome 2, this may intensify evening sleepiness and pre-dawn waking.
Eating most calories very early in the day can advance peripheral clocks. For Advanced sleep phase syndrome 2, this may reinforce an already early body clock and deepen the mismatch with typical social hours.
Alcohol can trigger earlier sleepiness and an earlier bedtime. In Advanced sleep phase syndrome 2, that often results in even earlier final awakening and fragmented late-night sleep.
Risk prevention
You can’t change the body clock traits behind Advanced sleep phase syndrome 2, but you can reduce how much it disrupts daily life. Small, steady habits that shift light, activity, and sleep timing often help you stay aligned with school, work, or family routines. Even if you can’t remove all risks, prevention can reduce their impact. Noticing early symptoms of Advanced sleep phase syndrome 2—like strong evening sleepiness and very early waking—can guide which steps to try first.
Use a bright light box or well-lit spaces for 30–90 minutes in the early evening. This can gently shift your sleep time later over days to weeks.
Use blackout curtains and consider sunglasses outside early in the morning. Limiting early-morning light can help prevent Advanced sleep phase syndrome 2 from pulling your sleep even earlier.
Keep a regular bedtime and wake time, even on weekends. Small shifts later—kept the same each day—are more likely to stick.
Only use melatonin with clinician guidance, since timing matters. For some with Advanced sleep phase syndrome 2, carefully timed morning doses may help delay the body clock but can cause daytime sleepiness.
Transmission
Advanced sleep phase syndrome 2 isn’t contagious or spread between people. It’s usually inherited in an autosomal dominant way, meaning one altered copy from either parent is enough; if a parent has Advanced sleep phase syndrome 2, each child has about a 50% (1 in 2) chance to inherit it.
Sometimes it appears for the first time in a family because of a new gene change. The genetic transmission of Advanced sleep phase syndrome 2 can show different strengths, so relatives with the condition may have earlier bedtimes to different degrees.
When to test your genes
Consider genetic testing if you consistently fall asleep and wake very early, especially if close relatives do too, or if symptoms began in adolescence. Testing can confirm a PER2-related form, guide tailored sleep timing, light therapy, and melatonin use, and rule out other causes. Ask your clinician or a genetic counselor about benefits, limits, and insurance coverage.
Diagnosis
Advanced sleep phase syndrome 2 can show up in everyday life as getting very sleepy in the early evening and waking hours before sunrise, even on weekends. For many, this affects family time, social plans, and work schedules. Many people feel relief just knowing what’s really going on. The diagnosis of Advanced sleep phase syndrome 2 is usually based on your sleep pattern and timing, then confirmed with targeted tests that look at your body’s internal clock.
Providers look for a stable pattern of early evening sleepiness and very early morning awakenings lasting at least several weeks. The schedule is usually consistent, not just a few off nights.
You’ll track bedtimes, wake times, naps, and caffeine or alcohol for 2–4 weeks. This record helps show your natural sleep window on workdays and free days.
A wrist device records movement to estimate sleep and wake times over 1–2 weeks. It provides an objective picture that often confirms an advanced sleep phase.
Saliva or blood samples collected under dim light measure when melatonin rises for the evening. An earlier-than-expected melatonin onset supports an advanced internal clock.
Stages of Advanced sleep phase syndrome 2
Advanced sleep phase syndrome 2 does not have defined progression stages. It describes a stable shift in the body’s sleep timing—tending to get sleepy very early and wake very early—rather than a condition that worsens step by step. Doctors usually start with a conversation about your sleep schedule and daily routine, then may ask for 1–2 weeks of sleep logs or a wearable sleep study (actigraphy). To confirm the pattern and rule out other causes, your team may check for early symptoms of Advanced sleep phase syndrome 2 during history-taking, and sometimes use evening melatonin timing tests or review other sleep disorders with overnight studies if needed.
Outlook and prognosis
Sleep and wake times often shift earlier in Advanced sleep phase syndrome 2, which can ripple into work, school, and social plans. Many people ask, “What does this mean for my future?”, and the short answer is that the condition itself isn’t life-threatening, but it can affect mood, alertness, and quality of life if schedules can’t flex. Doctors call this the prognosis—a medical word for likely outcomes. People with Advanced sleep phase syndrome 2 often do well when they can align their day to their natural rhythm or use targeted strategies like bright-light timing and consistent routines.
Some people experience stable, lifelong early sleep timing, while others notice it changes a bit with age, seasons, or stress. The risk of accidents from drowsiness in the late afternoon or very early morning is the main safety concern; mortality isn’t known to be directly higher from Advanced sleep phase syndrome 2 itself. Early symptoms of Advanced sleep phase syndrome 2 can include getting sleepy very early in the evening and waking up before dawn, which can strain relationships and mood if others keep later hours. With ongoing care, many people maintain a full work and family life by adjusting shifts, using planned naps, and timing light exposure to extend evening alertness when needed.
In medical terms, the long-term outlook is often shaped by both genetics and lifestyle. Genetic testing can sometimes provide more insight into prognosis, especially if a known clock-gene change is suspected, but not everyone with the same gene change will have the same outlook. Talk with your doctor about what your personal outlook might look like, including how to prevent drowsy driving and how to time light, melatonin, or exercise. Even though it can feel overwhelming, small, steady adjustments tend to add up and help people with Advanced sleep phase syndrome 2 feel and function better over time.
Long-term effects
Advanced sleep phase syndrome 2 tends to be a lifelong circadian pattern rather than a short-term issue. People often feel sleepy much earlier in the evening and wake very early, which can sit at odds with work or social schedules. Long-term effects vary widely, and the impact often depends on how flexible daily routines can be. Early features of Advanced sleep phase syndrome 2 may show up in adolescence or early adulthood and usually remain fairly stable across life.
In Advanced sleep phase syndrome 2, people fall asleep very early, often around 19:00–21:00 (7–9 pm). This pattern tends to persist year after year. Pushing bedtime later often leads to shorter sleep.
Many wake well before dawn, commonly 03:00–05:00 (3–5 am), often without an alarm. Alertness may peak in the early morning hours. If bedtime was delayed, waking still occurs early, cutting total sleep time.
Strong sleepiness builds in the early evening. Attention, reaction time, and memory can dip late at night. This can raise error risks when driving or working late.
Advanced sleep phase syndrome 2 can clash with school demands, shift work, or late social plans. Over time, daily routines may feel out of sync with family or coworkers. The mismatch can strain relationships and schedules.
How is it to live with Advanced sleep phase syndrome 2?
Mornings can feel effortless, with sleepiness arriving very early in the evening and spontaneous wake-ups before dawn; the challenge is that work, school, and social life rarely run on that clock. Many living with advanced sleep phase syndrome 2 plan evening activities carefully, use bright light in the late afternoon or early evening, and dim light at night to nudge their schedule later, but shifts or late events can still lead to missed gatherings or feeling out of sync. Family members or partners may notice mismatched bedtimes and wake times, which can affect shared routines; clear communication and small compromises—like quiet morning routines or scheduling earlier dinners—often help. With understanding at home and flexibility at work or school, most people can keep healthy sleep while staying connected to others.
Treatment and drugs
Treatment for advanced sleep phase syndrome 2 focuses on shifting the body clock later and improving sleep quality. Bright light therapy in the evening is the mainstay: sitting in front of a certified light box for about 30–90 minutes a few hours before your usual bedtime can help delay your natural sleep time over days to weeks; sunglasses or dimmer light in the early morning can prevent unintended early shifting. Low-dose melatonin timed in the early morning (not at night) may also help delay the internal clock; a doctor may adjust your dose to balance benefits and side effects. Keeping a stable schedule, avoiding bright light and screens early in the morning, and planning social or work activities later in the day reinforce these changes. Although living with advanced sleep phase syndrome 2 can feel overwhelming, many people manage their symptoms and live fulfilling lives.
Non-drug treatment
You might fall asleep very early and wake before dawn, which can disrupt family time and work. Non-drug treatments often lay the foundation for shifting your internal clock later. With Advanced sleep phase syndrome 2, the goal is to add light in the evening and reduce light first thing in the morning while keeping routines steady. For many, the early symptoms of Advanced sleep phase syndrome 2 are manageable with simple, consistent steps.
Use a bright light box or well-lit environment for a set period in the early evening to nudge your body clock later. Sit at a safe distance and keep your eyes open but not staring directly at the source.
Wear dark, wraparound sunglasses during early-morning commutes and limit outdoor light right after waking. Keep indoor lights dim in the first hour to avoid reinforcing the early schedule.
Set a target bedtime and wake time that are a bit later, then shift by 15–30 minutes every few days. Hold steady once you reach your goal, even on weekends.
Gradually delay sleep and wake times in a structured way over days to weeks. This approach works best with guidance from a sleep specialist to keep the shift safe and stable.
Your genes may have an impact on how drugs work for you
Some people with advanced sleep phase syndrome 2 process sleep-related medications differently because enzyme genes act like dimmer switches, speeding or slowing drug breakdown. Variants in clock genes can also shift how well melatonin or light therapy aligns the body’s timing.
Pharmacological treatments
People with Advanced sleep phase syndrome 2 often fall asleep very early and wake up before dawn, which can disrupt work, school, and family time. Medicines can help shift the body clock later or simply ease evening alertness and early-morning waking, but timing is everything and usually pairs with evening light therapy and consistent routines. You might picture medicine as one tool among many—alongside light therapy, steady routines, and sleep coaching. Below are commonly discussed medications for advanced sleep phase syndrome 2; some are off‑label and should be used with guidance from a sleep specialist.
Low-dose melatonin taken soon after waking can nudge the sleep clock later. This approach aims to delay bedtime over days to weeks but may cause daytime sleepiness.
Ramelteon and tasimelteon act on melatonin pathways and may be timed in the morning to promote a phase delay in Advanced sleep phase syndrome 2. If one option isn’t effective, second-line or alternative drugs may be offered.
Carefully timed propranolol in the late afternoon or evening can blunt the body’s natural melatonin signal to help delay sleep. Dosing may be increased or lowered gradually to find the smallest amount that helps without side effects.
Modafinil or armodafinil (prescription) and, more simply, caffeine can improve late‑day alertness so people with Advanced sleep phase syndrome 2 can stay up later. Drugs that target symptoms directly are called symptomatic treatments.
Genetic influences
In many families, sleep timing that shifts noticeably earlier is inherited, and Advanced sleep phase syndrome 2 is one condition where a single change in a “body clock” gene can nudge the sleep–wake cycle forward. Family history is one of the strongest clues to a genetic influence. This pattern is often passed from one parent to a child, so each child has about a 50% chance of inheriting the same gene change. The same change doesn’t affect everyone equally; light exposure, work routines, and age can make the shift milder or more pronounced. For some, early symptoms of Advanced sleep phase syndrome 2 appear in the teen years or early adulthood, when falling asleep very early and waking before dawn start to create conflicts with school, work, or social life. Some people consider genetic testing; if you do, meeting with a genetic counselor can help you understand what the results mean for you and your family.
Is Advanced sleep phase syndrome 2 genetic?
Genetics play a major role in Advanced sleep phase syndrome 2. Variants in clock-related genes can shift the internal body clock earlier, causing earlier sleep and wake times. Family clustering is common, suggesting strong heritability alongside environmental influences.
Pharmacogenetics—how genetics influence drug effects
Treatment often relies on timed evening light to shift the body clock later, and in some cases carefully timed melatonin or melatonin‑like medicines. Genes can influence how quickly you break down melatonin, caffeine, and certain sleep medicines, which can change the best dose and timing for you. In Advanced sleep phase syndrome 2, that means one person may do well with a very small, well‑timed dose, while another may need a different schedule or an alternative approach.
Differences in caffeine metabolism can matter if you use coffee or tea to stay awake later; slower breakdown can cause nighttime jitters, while faster breakdown may make caffeine less helpful. Sleep aids and melatonin‑pathway prescriptions are processed by liver enzymes that vary from person to person, so side effects like morning grogginess or dizziness—and how well the drug works—can differ. Targeted genetic results, when available, can help your clinician personalize the plan, but they’re used alongside a sleep diary, light exposure habits, work hours, and other medicines to guide treatment of Advanced sleep phase syndrome 2.
Interactions with other conditions
Early bedtimes and very early wake‑ups can clash with work or family routines, and when depression or anxiety are also present, lost sleep from this mismatch may make mood symptoms feel heavier. Advanced sleep phase syndrome 2 can overlap with insomnia—many fall asleep quickly but wake hours too early and can’t return to sleep—which often leads to daytime sleepiness and trouble concentrating. Doctors call it a “comorbidity” when two conditions occur together. When Advanced sleep phase syndrome 2 occurs alongside obstructive sleep apnea or restless legs, broken sleep can intensify early awakenings; treating those sleep disorders often improves both the sleep schedule and daytime energy. Early symptoms of Advanced sleep phase syndrome 2 can be mistaken for depression‑related early morning awakening, so assessing for both can help tailor care. Advanced sleep phase syndrome 2 can also make night‑shift work and late social schedules especially hard, and that long‑term misalignment may contribute to higher stress or blood pressure in some people. If you’re also managing diabetes or heart disease, keeping regular timing for meals, activity, medications, and morning light exposure can support a steadier body clock and may help those conditions stay on track.
How genes can cause diseases
Humans have more than 20,000 genes, each carrying out one or a few specific functions in the body. One gene instructs the body to digest lactose from milk, another tells the body how to build strong bones and another prevents the body's cells from beginning to multiply uncontrollably and developing into cancer. As all of these genes combined are the building instructions for our body, a defect in one of these genes can have severe health consequences.
Through decades of genetic research, we know the genetic code of any healthy/functional human gene. We have also identified that in certain positions on a gene, some individuals may have a different genetic letter from the one you have. We call these hotspots "Genetic Variations" or "Variants" in short. In many cases, studies have been able to show that having the genetic letter "G" in the position makes you healthy, but having the letter "A" in the same position disrupts the gene function and causes a disease. Genopedia allows you to view these variants in genes and summarizes all that we know from scientific research, which genetic letters (Genotype) have good or bad consequences on your health or on your traits.
History
Throughout history, people have described family members who fell asleep very early in the evening and woke before dawn, long before alarm clocks existed. A grandparent who nodded off right after dinner and started chores at 4 a.m. might have simply been called an “early bird.” These everyday stories match what doctors now recognize as a body-clock condition that shifts sleep to earlier hours.
From early theories to modern research, the story of Advanced sleep phase syndrome 2 reflects how sleep science has matured. Early medical notes grouped all “extreme morning types” together. As sleep labs spread in the late 20th century, researchers used body temperature and melatonin timing to show that some people truly run on an earlier internal schedule. These careful measurements helped separate a consistent, inherited pattern from habits or lifestyle.
In recent decades, knowledge has built on a long tradition of observation. Families who noticed similar sleep patterns across generations took part in studies, and DNA research now explains why some forms run so strongly in families. Scientists identified variants in clock-related genes in a subset of people with advanced sleep phase, and later recognized that not all early-sleep patterns share the same genetic cause. This led to the idea that there are subtypes, sometimes referred to as “type 2,” when the timing shift and family pattern are present but linked to a different, more recently described genetic change or mechanism.
Initially understood only through symptoms, later work clarified how these patterns can vary with age. Many living with Advanced sleep phase syndrome 2 say their earliest memories include dozing off during evening events and waking naturally before sunrise, and relatives often report the same. Over time, descriptions became more precise, distinguishing everyday preference from a circadian rhythm set earlier than the local day-night cycle.
Once considered rare, now recognized as a legitimate circadian rhythm condition, Advanced sleep phase syndrome 2 sits within the broader history of chronobiology—the study of daily rhythms. As methods improved, researchers learned to track the internal clock without being misled by work schedules, caffeine, or screen time, which made earlier reports clearer in hindsight. Not every early description was complete, yet together they built the foundation of today’s knowledge.
Today’s understanding grew from this path: home observations, clinic-based sleep timing, and then genetics. That progression explains why naming has shifted and why different labels sometimes appear in older articles. Looking back helps explain why many people went years thinking their pattern was simply a quirk, when in fact it reflects a stable, biologically driven rhythm that tends to run in families.